The heart and liver are organs that are closely related in both health and disease patients who undergo liver transplantation may suffer from heart disease that is a related to the original cause of the liver disease such as hemochromatosis b related to the liver disease itself or c related to other associated conditions. Neurological complications are common after liver transplantation as they affect up to one third of the transplanted patients and are associated with significant morbidity the introduction of calcineurin inhibitors cyclosporine a and tacrolimus in immunosuppressive regimens significantly improved the outcome of solid organ transplantation even though immunosuppression associated . The moment of introduction of clinical organ transplantations varied in western europe from country to country in retrospect one can distinguish pioneering countries most notably the uk and france and countries that were early or late adopters of the new technologies. The global diffusion of organ transplantation trends drivers and policy implications sarah l white a richard hirth b to 1995 across the countries belonging to the organisation providing kidney liver heart lung and pancreas transplantation either locally or via formal
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